Published physiology
Peer-reviewed work and established scientific literature used to ground autonomic regulation, HRV, sleep, metabolism, rPPG and related mechanisms.
Follow the evidence behind the framework. See what is established, what MI.BO. has observed, what is still being investigated, and every source cited in You Are NeuraGripped.
NeuraGrip separates published physiology from MI.BO. observations and from hypotheses that still require prospective validation.
Peer-reviewed work and established scientific literature used to ground autonomic regulation, HRV, sleep, metabolism, rPPG and related mechanisms.
Patterns seen in MI.BO. datasets or internal wellness observations. These are presented as observations, not universal causal findings.
New constructs, proposed relationships and mechanistic questions that remain open to formal validation and prospective study.
The bibliography spans physiology, stress biology, sleep, metabolism, ageing, interoception, environment, posture, GLP-1 science and muscle preservation.
Vagal function, neurovisceral integration, HRV standards and recovery dynamics.
Cumulative physiological demand, HPA-axis behaviour and the cortisol awakening response.
Sleep-wake timing, endocrine function and light-related disruption.
Biomechanics, restorative environments, screen exposure and exercise physiology.
Therapeutic efficacy, vagal pathways, autonomic effects, plateau, discontinuation and body composition.
Foundational camera-based pulse sensing and the measurement context behind remote physiological observation.
A citation should not decorate a claim. It should let the reader inspect the source, its use and its limits.
The statement being made in the book, report or platform.
Established, Observed or Investigating.
The specific proposition the source is being used to support.
What the paper cannot establish and what should not be inferred.
The archived paper or bibliographic record in the MI.BO. Evidence Vault.
The printed bibliography is preserved exactly by reference number. Reference 79b is retained as a supplemental record rather than silently renumbered.
Thayer, J. F., & Lane, R. D. (2007). The role of vagal function in the risk for cardiovascular disease and mortality. Biological Psychology, 74(2), 224-242.
Thayer, J. F., & Lane, R. D. (2000). A model of neurovisceral integration in emotion regulation and dysregulation. Journal of Affective Disorders, 61(3), 201-216.
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010). The relationship of autonomic imbalance, heart rate variability, and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), 122-131.
Berthoud, H. R., & Neuhuber, W. L. (2000). Functional and chemical anatomy of the afferent vagal system. Autonomic Neuroscience: Basic and Clinical, 85(1-3), 1-17.
Tsuji, H., et al. (1996). Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation, 94(11), 2850-2855.
Benichou, T., et al. (2018). Heart rate variability in type 2 diabetes mellitus: a systematic review and meta-analysis. PLOS ONE, 13(4), e0195166.
Nunan, D., Sandercock, G. R., & Brodie, D. A. (2010). A quantitative systematic review of normal values for short-term HRV in healthy adults. Pacing and Clinical Electrophysiology, 33(11), 1407-1417.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996). Heart rate variability: standards of measurement, physiological interpretation, and clinical use. European Heart Journal, 17(3), 354-381.
Shaffer, F., & Ginsberg, J. P. (2017). An overview of heart rate variability metrics and norms. Frontiers in Public Health, 5, 258.
Lehrer, P. M., & Gevirtz, R. (2014). Heart rate variability biofeedback: how and why does it work? Frontiers in Psychology, 5, 756.
Verkruysse, W., Svaasand, L. O., & Nelson, J. S. (2008). Remote plethysmographic imaging using ambient light. Optics Express, 16(26), 21434-21445.
de Haan, G., & Jeanne, V. (2013). Robust pulse rate from chrominance-based rPPG. IEEE Transactions on Biomedical Engineering, 60(10), 2878-2886.
McEwen, B. S., & Stellar, E. (1993). Stress and the individual: mechanisms leading to disease. Archives of Internal Medicine, 153(18), 2093-2101.
McEwen, B. S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338(3), 171-179.
McEwen, B. S. (2008). Central effects of stress hormones in health and disease. European Journal of Pharmacology, 583(2-3), 174-185.
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience & Biobehavioral Reviews, 35(1), 2-16.
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55-89.
Adam, E. K., et al. (2017). Diurnal cortisol slopes and health outcomes: a systematic review and meta-analysis. Psychoneuroendocrinology, 83, 25-41.
Wüst, S., Wolf, J., Hellhammer, D. H., Federenko, I., Schommer, N., & Kirschbaum, C. (2000). The cortisol awakening response, normal values and confounds. Noise and Health, 2(7), 79-88.
Clow, A., Hucklebridge, F., Stalder, T., Evans, P., & Thorn, L. (2010). The cortisol awakening response: more than a measure of HPA axis function. Neuroscience & Biobehavioral Reviews, 35(1), 97-103.
Stalder, T., et al. (2016). Assessment of the cortisol awakening response: expert consensus guidelines. Psychoneuroendocrinology, 63, 414-432.
Wüst, S., Federenko, I., Hellhammer, D. H., & Kirschbaum, C. (2000). Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology, 25(7), 707-720.
Kahn, B. B., & Flier, J. S. (2000). Obesity and insulin resistance. Journal of Clinical Investigation, 106(4), 473-481.
Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. Journal of Clinical Investigation, 106(2), 171-176.
DeFronzo, R. A. (2004). Pathogenesis of type 2 diabetes mellitus. Medical Clinics of North America, 88(4), 787-835.
Epel, E. S., et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences, 101(49), 17312-17315.
Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14(10), R115.
Zannas, A. S., et al. (2015). Lifetime stress accelerates epigenetic aging in an urban, African American cohort. Proceedings of the National Academy of Sciences, 112(42), E6003-E6012.
Oh, H. S.-H., et al. (2023). Organ aging signatures in the plasma proteome track health and disease. Nature, 624, 164-172.
Ahadi, S., et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine, 26(1), 83-90.
Levine, P. A. (1997). Waking the Tiger: Healing Trauma. North Atlantic Books. [Clinical framework text; not a controlled research study.]
Payne, P., Levine, P. A., & Crane-Godreau, M. A. (2015, corrected). Somatic experiencing: using interoception and proprioception as core elements of trauma therapy. Frontiers in Psychology, 6, 93.
van der Kolk, B. A. (2014). The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma. Viking. [Clinical synthesis text; not a controlled research study.]
Dishman, R. K., et al. (2006). Neurobiology of exercise. Obesity (Silver Spring), 14(3), 345-356.
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004). Effect of exercise training on endothelium-derived nitric oxide function in humans. The Journal of Physiology, 561(1), 1-25.
Tanaka, H., Dinenno, F. A., Monahan, K. D., Clevenger, C. M., DeSouza, C. A., & Seals, D. R. (2000). Aging, habitual exercise, and dynamic arterial compliance. Circulation, 102(11), 1270-1275.
Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74(2), 116-143.
Grossman, P. (2023). Fundamental challenges and likely refutations of the five basic premises of the polyvagal theory. Biological Psychology, 180, 108589. [Critical review; included for balanced representation of the literature.]
Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine, 40(2), 218-227.
Teo, J. T., Johnstone, S. J., Römer, S. S., & Thomas, S. J. (2022). Psychophysiological mechanisms underlying the potential health benefits of human-dog interactions: A systematic literature review. International Journal of Psychophysiology, 180, 27-48.
LeDoux, J. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155-184.
LeDoux, J. E., & Pine, D. S. (2016). Using neuroscience to help understand fear and anxiety: a two-system framework. American Journal of Psychiatry, 173(11), 1083-1093.
Critchley, H. D., & Harrison, N. A. (2013). Visceral influences on brain and behavior. Neuron, 77(4), 624-638.
Czeisler, C. A., & Buxton, O. M. (2017). The human circadian timing system and sleep-wake regulation. In Kryger, Roth & Dement (Eds.), Principles and Practice of Sleep Medicine (6th ed.), Elsevier.
Spiegel, K., Leproult, R., & Van Cauter, E. (1999). Impact of sleep debt on metabolic and endocrine function. The Lancet, 354(9188), 1435-1439.
Ulrich, R. S., et al. (1991). Stress recovery during exposure to natural and urban environments. Journal of Environmental Psychology, 11(3), 201-230.
Kaplan, S. (1995). The restorative benefits of nature: toward an integrative framework. Journal of Environmental Psychology, 15(3), 169-182.
Taylor, R. P., et al. (2006). Reduction of physiological stress using fractal art and architecture. Leonardo, 39(3), 245-251. [Fractal visual complexity and stress reduction.]
Chen, H., Tse, M. M. Y., Chung, J. W. Y., Yau, S. Y., & Wong, T. K. S. (2023). Effects of posture on heart rate variability in non-frail and prefrail individuals: a cross-sectional study. BMC Geriatrics, 23, 870.
Hansraj, K. K. (2014). Assessment of stresses in the cervical spine caused by posture and position of the head [biomechanical model; Surgical Technology International, low-impact letter; load values are modelling estimates]. Surgical Technology International, 25, 277-279. PMID:25393825.
Rosenfield, M. (2011). Computer vision syndrome: a review of ocular causes and potential treatments [ocular symptoms; not autonomic activation]. Ophthalmic and Physiological Optics, 31(5), 502-515.
Sheppard, A. L., & Wolffsohn, J. S. (2018). Digital eye strain: prevalence, measurement and amelioration. BMJ Open Ophthalmology, 3(1), e000146. doi:10.1136/bmjophth-2018-000146.
Chang, A. M., et al. (2015). Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proceedings of the National Academy of Sciences, 112(4), 1232-1237. [Evening light-emitting screen exposure, melatonin suppression, circadian delay, sleep disruption, and next-morning alertness.]
Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (STEP 1 Study Group) (2021). Once-weekly semaglutide in adults with overweight or obesity (STEP 1). New England Journal of Medicine, 384(11), 989-1002.
Jastreboff, A. M., et al. (2022). Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1). New England Journal of Medicine, 387, 205-216.
Brierley, D. I., & de Lartigue, G. (2022). Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating. British Journal of Pharmacology, 179(4), 584-599.
Sun, F., Wu, S., Guo, S., et al. (2015). Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among subjects with type 2 diabetes: a systematic review and network meta-analysis. Diabetes Research and Clinical Practice, 110, 26-37.
Grosicki, G. J., Kim, J., Fielding, F., et al. (2025). Heart and health behavior responses to GLP-1 receptor agonists: a 12-week study using wearable technology and causal inference. American Journal of Physiology–Heart and Circulatory Physiology, 328(2), H235-H241.
Hall, K. D. (2024). Physiology of the weight-loss plateau in response to diet restriction, GLP-1 receptor agonism, and bariatric surgery. Obesity (Silver Spring), published April 2024, 32(6), 1163-1168.
Hansen, C. S., Frandsen, C. S., Fleischer, J., et al. (2019). Liraglutide-induced weight loss may be affected by autonomic regulation in type 1 diabetes. Frontiers in Endocrinology, 10, 242. [Lira-1 RCT; n=99 (50 liraglutide/49 placebo), overweight type 1 diabetes; cited as a mechanistic signal for the autonomic–GLP-1 interaction, not population-level proof.]
Berg, S., Stickle, H., Rose, S. J., & Nemec, E. C. (2025). Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: a systematic review and meta-analysis. Obesity Reviews, 26(8), e13929.
Wilding, J. P. H., Batterham, R. L., Davies, M., et al. (STEP 1 Study Group) (2022). Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes, Obesity and Metabolism, 24(8), 1553-1564.
Rubino, D., Abrahamsson, N., Davies, M., et al. (STEP 4 Investigators) (2021). Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial. JAMA, 325(14), 1414-1425.
Aronne, L. J., Sattar, N., Horn, D. B., et al. (SURMOUNT-4 Investigators) (2024). Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial. JAMA, 331(1), 38-48.
Liu, Q. K. (2024). Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists. Frontiers in Endocrinology, 15, 1431292.
Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (STEP 1 Study Group) (2021). Impact of Semaglutide on Body Composition in Adults With Overweight or Obesity: Exploratory Analysis of the STEP 1 Study. Journal of the Endocrine Society, 5(Suppl 1), A16-A17.
Alissou, M., Demangeat, T., Folope, V., et al. (2026). Impact of semaglutide on fat mass, lean mass and muscle function in patients with obesity: the SEMALEAN study. Diabetes, Obesity and Metabolism, 28(1), 112-121.
Acanfora, D., et al. (2022). Impaired vagal activity in long-COVID-19 subjects. Viruses, 14(5), 1035.
Marques, K. C., et al. (2022). Reduction of cardiac autonomic modulation and increased sympathetic activity in subjects with long COVID. Frontiers in Cardiovascular Medicine, 9, 862001.
Asarcikli, L. D., et al. (2022). Heart rate variability and cardiac autonomic functions in post-COVID period. Journal of Interventional Cardiac Electrophysiology, 63(3), 715-721.
Camici, M., Del Duca, G., Brita, A. C., & Antinori, A. (2024). Connecting dots of long COVID-19 pathogenesis: a vagus nerve–hypothalamic-pituitary-adrenal–mitochondrial axis dysfunction. Frontiers in Cellular and Infection Microbiology, 14, 1501949.
Woo, M. S., Shafiq, M., Fitzek, A., et al. (2023). Vagus nerve inflammation contributes to dysautonomia in COVID-19. Acta Neuropathologica, 146(3), 387-394.
Moore, D. R., Robinson, M. J., Fry, J. L., et al. (2009). Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. American Journal of Clinical Nutrition, 89(1), 161-168.
Herreman, L., Nommensen, P., Pennings, B., & Laus, M. C. (2020). Comprehensive overview of the quality of plant- and animal-sourced proteins based on the digestible indispensable amino acid score. Food Science & Nutrition, 8(10), 5379-5391.
Jalleh, R. J., Plummer, M. P., Marathe, C. S., Umapathysivam, M. M., Quast, D. R., Rayner, C. K., Jones, K. L., Wu, T., Horowitz, M., & Nauck, M. A. (2025). Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide. Journal of Clinical Endocrinology & Metabolism, 110(1), 1-15. Correction: 110(10), e3556.
Boirie, Y., Dangin, M., Gachon, P., Vasson, M. P., Maubois, J. L., & Beaufrère, B. (1997). Slow and fast dietary proteins differently modulate postprandial protein accretion. Proceedings of the National Academy of Sciences, 94(26), 14930-14935.
Churchward-Venne, T. A., Burd, N. A., Mitchell, C. J., et al. (2012). Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. The Journal of Physiology, 590(11), 2751-2765.
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2022). A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation. iScience, 25(9), 104869.
Neeland, I. J., Linge, J., & Birkenfeld, A. L. (2024). Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes, Obesity and Metabolism, 26(Suppl. 4), 16-27.
Sattar, N., Neeland, I. J., Dahlqvist Leinhard, O., et al. (2025). Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial. The Lancet Diabetes & Endocrinology, 13(6), 482-493.
Budini, B., Luo, S., et al. (2026). Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression. eClinicalMedicine, 93, 103796.
Tzang, C. C., Wu, P. H., Luo, C. A., et al. (2025). Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis. eClinicalMedicine, 90, 103680.
Each evidence record opens in the MI.BO. Science Library, where available source material, citation context and limitations can be reviewed together.
NeuraGrip is one part of a broader MI.BO. evidence library spanning MIBOSelfie, METAHUMAN, REFLECT and related work in physiology, bio-intelligence and human performance.
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